Core lookup before generic guides
Arcana Guide
Arcana effects can change a run before the first card is played. Treat them as build-defining systems, not optional flavor.
Experimental Medicine
Shield Bash
Wild Buff
Jester's Hat
Chain Link
Your Shield My Liege
Swollen Fist
And Another
Make a Scene
Over The Top
Sharp Mind
Mana Syphon
Experimental Medicine
Experimental Medicine
Doubles healing from cards and items.
Unlocked automatically when the Fortune Teller tent opens.
Best for early sustain, Clerici-style healing, and forgiving beginner routes.
Shield Bash
Shield Bash
Armor cards deal damage equal to the Armor they provide.
Unlocked automatically when the Fortune Teller tent opens.
Turns defensive drafting into damage; pairs with armor-heavy relics.
Wild Buff
Wild Buff
Cards picked up from light sources are affected by combo multipliers.
Play 200 cards found by breaking light sources.
Excellent when the run already wants Wild cards and environmental drops.
Jester's Hat
Jester's Hat
Guarantees a Wild card drop on every floor.
Find and play 150 Wild cards.
Stabilizes ascending-mana and combo decks.
Chain Link
Chain Link
Combo multipliers do not clear between turns.
Reach a combo chain of 12 or higher in one turn.
Core engine for high-scaling Tome/Wild decks.
Your Shield My Liege
Your Shield My Liege
Remaining Armor carries between turns.
Gain a total of 2,000 Armor.
Makes defensive turns snowball instead of wasting excess Armor.
Swollen Fist
Swollen Fist
At end of turn, deal damage based on total deck size.
Reach exactly or at least 40 cards in deck; wording needs in-game confirmation.
Rewards large decks, but fights against normal deck-thinning logic.
And Another
And Another
Repeated cards played during the same turn become free.
Play Free-to-Play cards; most current lists say 150, one research pass found a 500-card conflict.
Core for loop decks and expensive-hand turns.
Make a Scene
Make a Scene
Crawler abilities automatically trigger at the start of every turn.
Activate Crawler trigger abilities 1,500 times.
Excellent with high-value Crawler passives and multi-character parties.
Over The Top
Over The Top
When a Crawler card is lost, it returns to your hand next turn.
Play Crawler cards 100 times.
Lets Crawler cards become a repeatable engine instead of one-off value.
Sharp Mind
Sharp Mind
Save up to 5 unspent Mana between turns.
Play 100 purple cards.
Smooths awkward turns and enables big setup turns.
Mana Syphon
Mana Syphon
Gain +1 Mana for the rest of the run every time you play 100 cards.
Gain 15 Mana or more in one turn.
One of the clearest snowball Arcana choices for draw-heavy decks.
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