Core lookup before generic guides

Arcana Guide

Arcana effects can change a run before the first card is played. Treat them as build-defining systems, not optional flavor.

12Arcana entries
1equipped at a time, per current guide sources
12entries kept tidy

Experimental Medicine

Experimental Medicine

HealingStarter
Effect

Doubles healing from cards and items.

Unlock

Unlocked automatically when the Fortune Teller tent opens.

Use case

Best for early sustain, Clerici-style healing, and forgiving beginner routes.

Shield Bash

Shield Bash

ArmorDamageStarter
Effect

Armor cards deal damage equal to the Armor they provide.

Unlock

Unlocked automatically when the Fortune Teller tent opens.

Use case

Turns defensive drafting into damage; pairs with armor-heavy relics.

Wild Buff

Wild Buff

WildCombo
Effect

Cards picked up from light sources are affected by combo multipliers.

Unlock

Play 200 cards found by breaking light sources.

Use case

Excellent when the run already wants Wild cards and environmental drops.

Jester's Hat

Jester's Hat

WildCombo
Effect

Guarantees a Wild card drop on every floor.

Unlock

Find and play 150 Wild cards.

Use case

Stabilizes ascending-mana and combo decks.

Your Shield My Liege

Your Shield My Liege

ArmorSustain
Effect

Remaining Armor carries between turns.

Unlock

Gain a total of 2,000 Armor.

Use case

Makes defensive turns snowball instead of wasting excess Armor.

Swollen Fist

Swollen Fist

Damagedeck
Effect

At end of turn, deal damage based on total deck size.

Unlock

Reach exactly or at least 40 cards in deck; wording needs in-game confirmation.

Use case

Rewards large decks, but fights against normal deck-thinning logic.

And Another

And Another

ComboMana
Effect

Repeated cards played during the same turn become free.

Unlock

Play Free-to-Play cards; most current lists say 150, one research pass found a 500-card conflict.

Use case

Core for loop decks and expensive-hand turns.

Make a Scene

Make a Scene

CrawlerCombo
Effect

Crawler abilities automatically trigger at the start of every turn.

Unlock

Activate Crawler trigger abilities 1,500 times.

Use case

Excellent with high-value Crawler passives and multi-character parties.

Over The Top

Over The Top

CrawlerCombo
Effect

When a Crawler card is lost, it returns to your hand next turn.

Unlock

Play Crawler cards 100 times.

Use case

Lets Crawler cards become a repeatable engine instead of one-off value.

Sharp Mind

Sharp Mind

ManaCombo
Effect

Save up to 5 unspent Mana between turns.

Unlock

Play 100 purple cards.

Use case

Smooths awkward turns and enables big setup turns.

Mana Syphon

Mana Syphon

ManaCombo
Effect

Gain +1 Mana for the rest of the run every time you play 100 cards.

Unlock

Gain 15 Mana or more in one turn.

Use case

One of the clearest snowball Arcana choices for draw-heavy decks.